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The beyond use date for an opened or entered (e.g., needle punctured) multiple-dose container with antimicrobial preservatives is 28 days, unless otherwise specified by the manufacturer

Since adipose tissue is responsive to endotoxins, bacterial translocation may provide a mechanism whereby the gut microbiome can modulate the adipose metabolome (for review, Kruis et al., 2014 23 ) and consequently exacerbate obesity and its related comorbidities