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No deviation in the tryptophan emission maxima after changing the pH of the protein solution from 2 to 11 suggests that the tertiary structure of the protein is not disturbed over a wide pH range (Fig 3A)

3,4 This receptor and its agonists hold significant therapeutic potential, reshaping the treatment approaches for multiple diseases, including diabetes, cardiovascular disorders, and neurodegenerative diseases

It is crucial that prescribing clinicians review: Current thyroid function tests (TSH, free T4, free T3) Cardiovascular status and any history of arrhythmias Renal function, particularly if there are concerns about dehydration Pre-existing diabetic retinopathy, which requires close monitoring Concurrent medications and potential drug interactions Patient's ability to recognise and report symptoms of thyroid dysfunction or medication side effects Important considerations before starting Mounjaro include: Pregnancy planning: Mounjaro is not recommended during pregnancy and should be discontinued at least 1 month before a planned pregnancy Oral contraceptive effectiveness may be reduced