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SLU-PP-332 is a small-molecule pan-ERR agonist with strongest potency at ERR that activates an exercise-like metabolic program in skeletal muscle, liver, and adipose tissue

Rapid and reliable measurement of drug encapsulation efficiency allows for the quick identification of promising candidates

"We should be insisting on having publicly accessible good diet and physical activity supports because we live in a society where people are gaining more and more weight," Dasgupta said

Elevations up to 2-3 times the upper limit of normal have been observed in semaglutide-treated patients without any clinical symptoms or imaging abnormalities

On average, this has led to a significant ~30-50% increase in muscle carnosine content with ~3-6 g beta-alanine supplemented/day over 4-6 weeks