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Importantly, he noted, the findings remained statistically significant even after adjustments were made for age and baseline BMI in the mix effect model

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It raises interesting questions around whether future strategies could further optimize outcomes through combination approaches or more targeted pathway modulation

Jens Juul Holst is professor of medical physiology at the Department of Biomedical Sciences, University of Copenhagen

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GSTs are able to conjugate glutathione (-l-glutamyl-l-cysteinyl-glycine, GSH) to a wide range of hydrophobic and electrophilic molecules including many carcinogens, therapeutic drugs, and many products of oxidative metabolism, making them less toxic and predisposed to further modification for discharge from the cell (Fig