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10.1016/j.tem.2012.07.006 Trends Endocrinol

Features of SIPS include increased senescence-associated -galactosidase (SA--Gal) activity, appearance of senescence-associated heterochromatin foci (SAHF), cell growth arrest, and increased expression of senescence-associated genes 11,34

Infrared (IR): Light just beyond visible red

The thiol couples are maintained in a reduced state in both compartments in order to protect against oxidative stress ( FIGURE 1 TABLE 1 Illustration of Diet-Induced Changes in the NAD/NADH Ratio in Rat Liver [data from Illustration of Mitochondrial ROS Production Reactive oxygen species is produced in the mitochondrial electron transport chain when ATP levels are sufficient and excess fuel generates elevated NADH

CoMo peptides are stable in lyophilized form for shipping

Short-course studies report no overt toxicity at commonly used doses, but programs should include organ-system panels, cardiovascular telemetry where relevant, and pathology review for chronic exposures