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(53) reported an increased expression of hyaluronan synthase 1 ( HAS1 ) for synovial fluid production and proteases such as MMP-1 and MMP-3, thus contributing to joint homeostasis

Irisin, for example, enhances thermogenesis by promoting expression of brown-fat-related genes, which expend more energy than ordinary fat

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This puts you into a temporary menopause-like state

doi: 10.3389/fnut.2018.00083 Morton RW, McGlory C, Phillips SM