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Without intervention, roughly 15 to 30% of people with prediabetes develop type 2 diabetes within five years

Start conservatively and adjust based on results

Future trials and observational registries must therefore include diverse populations and evaluate socioeconomic and demographic predictors of treatment uptake and adherence

Suitability considerations: Consistent with class precedents for GLP-1-based therapies, retatrutide would not be expected to be suitable during pregnancy or breastfeeding, and paediatric data are currently lacking

Note: A separate PA request must be obtained for maintenance treatment with Skyrizi subQ