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10.18632/aging.202774 249 YangG.GuanW.CaoZ.GuoW.XiongG.ZhaoF.et al (2021)

These three trials found no significant improvement in PASI scores, and the authors noted that the other trials varied widely in their methods and outcomes assessments (Yang 2019)

Skin loses its elasticity when fat disappears quickly, leaving loose tissue that diet and exercise struggle to correct