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Animal studies demonstrated thyroid C-cell tumors at clinically relevant exposures, and while the human risk remains uncertain, the FDA requires a boxed warning about this potential thyroid cancer risk

PPAR is primarily expressed in adipose tissue and thus it was at first difficult to reconcile how a drug that was apparently acting only in adipose tissue could lead to improved insulin sensitivity of other tissues

PMID 10714245

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These complications are the important causes of mortality among the affected people which impose a heavy economic burden on the healthcare systems globally

Besides, The mechanisms regulating GPX4 expression are ill-defined 53