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In humans, kidney removes 68 U of insulin per day by two major routes (Figure 2), that apparently have distinct preferential physiological goals: post-glomerular secretion (insulin signaling) and glomerular filtration (nutrient conservation and homeostasis) (Ritz et al., 2013)

In the PD Drosophila model, overexpression of Nrf2 and knockdown of Keap1 alleviate the decline in locomotor ability (170)

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