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SIRT3 lysine deacetylase inhibitors specifically target SIRT3 without affecting its structurally similar counterparts, SIRT1 and SIRT2 185,186

While these conditions differ in underlying causes, both result in joint pain, stiffness, reduced mobility, and progressive tissue damage

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NRF-1 and NRF-2 regulate nuclear and mitochondrial genes essential for various critical functions, such as oxidative phosphorylation (OXPHOS), electron transport chain complexes IV, mitochondrial DNA (mtDNA) transcription and replication, protein import and assembly, ion channel activity, molecular transport, and translation (47)

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Chronic reliance on antacids suggests inadequately controlled disease requiring more definitive intervention