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Combined treatments with anti-angiogenic agents (anti-VEGF or anti-VEGFR2) and ICB stimulated vessel normalization and the formation of HEV, favoring immune control of tumor progression (154, 155), and induced anti-tumor T cell responses (156)

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It is not a magic bullet and it will not do away with surgery or fix structural issues such as bone-on-bone arthritis, or reverse severe deformities

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We don't use a one-size-fits-all method because bodies don't work that way